MDM2

Oct 17, 11
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  • This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation .
  • AceView offers a comprehensive annotation of human, mouse and nematode genes reconstructed by co-alignment and clustering of all publicly available .
  • Sep 21, 2011 – Miscellaneous. MDM2 RING finger mutations that failed to ubiquitinate p53 in vitro did not target p53 for degradation when expressed in cells. .
  • by AG Herman - 2011
  • The SCOP classification for the SWIB/MDM2 domain superfamily including the families contained in it. Additional information provided includes InterPro .
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  • Feb 15, 2011 – The MDM2 Promoter SNP285C/309G Haplotype Diminishes Sp1 Transcription Factor Binding and Reduces Risk for Breast and Ovarian .
  • Approved Name +, Mdm2 p53 binding protein homolog (mouse) . Previous Symbols & Names +, "Mdm2, transformed 3T3 cell double minute 2, p53 binding .
  • by C Tovar - 2011 - Cited by 2 - Related articles
  • by B Cross - 2011 - Related articles
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  • by D Alarcon-Vargas - 2002 - Cited by 165 - Related articles
  • Mar 11, 2010 – HGNC name, Mdm2 p53 binding protein homolog (mouse). HGNC id, 6973. Location, 12q15. Synonym name, mouse double minute 2, human .
  • Complete information for MDM2 gene (protein-coding), Mdm2 p53 binding protein homolog (mouse)
  • Millipore's MDM2 antibody demonstrates specificity against MDM2. See below for data and references for Millipore's MDM2 antibodies. All Millipore antibodies .
  • www.infosci.coh.org/mdm2/dbabout.htmp73_p63You +1'd this publicly. UndoJump to Mdm2 discovery‎: mdm2. Barak, Y., and M. Oren (1992) EMBO J 11:2115-2121. Enhanced binding of a 95 kDa protein to p53 in cells undergoing .
  • MDM2 is an oncoprotein that acts as a cellular inhibitor of the p53 tumour suppressor by binding to the transactivation domain of p53 and suppressing its ability .
  • In this study, we performed selection of MDM2-binding peptides from large . We identified an optimal peptide named MIP that inhibited the MDM2-p53 and .
  • by CR Jung - 2010 - Related articles
  • Although MDM2, the product of mouse double minute-2 (mdm2) gene, or its human homologue possesses the potential to confer tumorigenic properties, .
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  • Specific antibody for the gene product of MDM2, the protein Mdm2, p53 binding protein. Validated for specificity by gene-silencing with siRNA followed by .
  • View and buy high quality MDM2 Clone 2G2 from Tocris Bioscience, the leading worldwide supplier of high performance life science reagents.
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  • by R Khosravi - 1999 - Cited by 305 - Related articles
  • This has been very clearly demonstrated by studies of transgenic mice where loss of either of the essential negative regulators of p53 (MDM2 or, more recently .
  • Gene name. MDM2, HDMX, MGC5370, MGC71221, hdm2. Definition. Mdm2 p53 binding protein homolog (mouse). Orthology. K06643, transformed 3T3 cell double minute .
  • Signaling to p53: breaking the MDM2-p53 circuit. A role for ATR in the DNA damage-induced phosphorylation of p53.
  • Description: Mdm2 p53 binding protein homolog (mouse) [Source:HGNC Symbol;Acc: 6973] . . MDM2-039, ENST00000540062, 296, No protein product .
  • When the Murine Double Minute (MDM2) gene is over-expressed it enhances the . MDM2 has been shown to be amplified in around 7% of human tumours. .
  • The activity and stability of p53 is modulated by the MDM2 oncoprotein. Binding to the transactivation domain of p53, MDM2 blocks its ability to activate .
  • Phospho-MDM2 (Ser166) Antibody detects endogenous levels of MDM2 only when . corresponding to residues surrounding Ser166 of human MDM2. .
  • Gene Symbol: mdm2. Previous Names: etID309863.4(1), zgc:109834. Nomenclature History . ANTIBODIES No data available. CONSTRUCTS WITH SEQUENCES FROM mdm2 .
  • Mdm2 is an important negative regulator of the p53 tumor suppressor. It is the name of a gene as well as the protein encoded by that gene. Mdm2 protein .
  • La proteína Mdm2 (de sus siglas en inglés "murine doble minute 2") es un importante regulador negativo del supresor tumoral p53. Mdm2 se corresponde con .
  • MDM2 is an oncogene that inhibits TP53 [0890]. The MDM2 gene encodes multiple transcripts, many of which are tissue-specific. Disruption of MDM2 in mice .
  • by S Dastidar - 2009 - Cited by 8 - Related articles
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  • MDM2 a ubiquitin ligase for p53, plays a central role in regulation of the stability of p53 via Akt-mediated MDM2 phosphorylation. Phosphorylation of MDM2 .
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  • mouse monoclonal IgG1; 200 µg/ml; raised against amino acids 154-167 of MDM2 of human origin; recommended for detection of MDM2, MDM2 p60 cleavage .
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  • by M Sasaki - 2011 - Cited by 2
  • Mouse Mdm2 Chr10:117125944-117147814 bp, - strand has data for genome coordinates, mammalian orthology, sequences, phenotypes, polymorphisms, .
  • by T Iwakuma - 2003 - Cited by 191 - Related articles
  • Past International MDM2 Workshop V Ghent, 23-26 August 2009. Venue : see Locations. The meeting takes place in two historical buildings of Ghent University : .
  • Mouse monoclonal [2A10] to MDM2 primary antibody datasheet (ab16895).

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