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In contrast to caretaker genes, gatekeeper genes encode gene products that act to prevent growth of potential cancer cells and prevent accumulation of .
In the caretaker pathway, multiple genes need to be inactivated in the cell to become neoplastic. First, two alleles of a caretaker gene are mutated. .
Inadequate "caretaker" gene function and human cancer development. DeWeese Theodore L; Nelson William G (Profiled Authors: Theodore Deweese; William Nelson ) .
by NC Levitt - 2002 - Cited by 72 - Related articles
The same report suggested that an individual who inherits a mutated .
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17 Sep 2000 . Caretaker gene: A class of genes that when inactivated do not directly promote tumours; instead their inactivation results in genetic .
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As with the gatekeeper TSGs, both copies of a caretaker TSG must be inactivated in order for a cell to completely lose the caretaker function of that gene. .
2 May 2000 . New Caretaker Gene Discovered (Back to Top) . Recognizing this additional role for the gene, called Ku80, could increase ways of targeting .
9 Oct 2008 . Finally, in the caretaker pathway (bottom) a total of four mutations, resulting in the inactivation of two alleles of a caretaker gene .
by KW Kinzler - 1998 - Cited by 383 - Related articles
by S Pucci - Cited by 1 - Related articles
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Thus, caretaker genes do not directly regulate cell proliferation. In genetic knock-out and rescue experiments, restoration of a caretaker gene from the .
by S Pucci - 2009 - Cited by 1 - Related articles
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Gene Therapy for Locally-Recurrent Prostate Cancer Following Radiation. . 40. DeWeese, T.L., and Nelson, W.G. Inadequate "caretaker" gene function and . .
The 'caretaker' pathway is initiated by mutations in both alleles of a caretaker gene (a gene that maintains genetic stability). .
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1 Jun 1998 . HNPCC patients, who have a caretaker gene defect, have normal tumor initiation, but accelerated tumor progression (3 to 5 years). .
As a "caretaker" gene, MYH is responsible for repairing DNA damage caused by reactive oxygen species that are generated during aerobic metabolism. .
1 Mar 2011 . "We're calling it a caretaker gene because in its absence you get many chromosomal rearrangement events, which are basically mutations," Dr. .
In the photos above, the cattle are being "unloaded from the trucks one at a time," says ranch caretaker Gene Matile. Mr. Matile is responsible for counting .
by S PUCCI - 2004 - Cited by 1 - Related articles
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As a caretaker gene disease and cancer predisposition syndrome, FA genes defects are . Epigenetic silence of FANCF gene by promoter region .
Almost irrespective of the specific nature of the tumor gene in question, the net result of caretaker gene mutation is to elevate the frequency of gene or .
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by I Bae - 2004 - Cited by 62 - Related articles
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by TL DeWeese - 2003 - Cited by 5 - Related articles
Caretaker gene Information - Human resources, Jobs, Training, Resume, Outsourcing, Consulting, Human resource management, Human Resources Management, .
by M Macaluso - 2003 - Cited by 35 - Related articles
10 Jan 2011 . Caretaker Gene - from WN Network. WorldNews delivers latest Breaking news including World News, U.S., politics, business, entertainment, .
29 Jun 2008 . Gene Bonee, caretaker at Hardin Point Hunting Club, casts off from Charlie's Camp at Tunica Cutoff. The flood waters have receded enough for .
by O Levran - 1997 - Cited by 89 - Related articles
by S de Vogel - 2009 - Cited by 7 - Related articles
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