www.homepages.ucl.ac.uk/. /Baron%20- %20Wnt%20LRP5%20review%202007.pdfCachedSimilarMar 29, 2007 . protein 5 (LRP5), a coreceptor for Wnts, and bone mass in humans and in mice.

www.xenbase.org/common/ViewImageActionNonAdmin.do?. CachedWise, Sost, and LRP5/6 localization in murine bone. (A–D) Sost

https://synapse.koreamed.org/search.php?where=aview. CachedMay 18, 2012 . Lipoprotein receptor-related protein (LRP5) signaling is well correlated with the

https://web.stanford.edu/group/nusselab/cgi-bin/wnt/arrow_LRPCachedSimilarWise and the related protein SOST/Sclerostin can also bind to LRP, to either .

mcb.asm.org/content/29/4/953.fullSimilarThe Wnt canonical signaling pathway mediated by LRP5 was found to promote .

jcb.rupress.org/content/182/5/865SimilarSep 1, 2008 . Wise and SOST were also found to interact with LRP5/6 and compete with Wnt

www.morphopedia.org/images/6/6c/Logan2004.pdfCachedJul 2, 2004 . The Wnt inhibitors Dickkopf (Dkk) and Wise bind to the Wnt coreceptors Arrow

www.jbc.org/content/280/29/26770.fullSimilarJul 22, 2005 . Interestingly, SOST is related to WISE, a secreted protein that binds to . Here we

digital.csic.es/bitstream/10261/. /Vitamin%20D%20and%20Wnt.pdfCachedSimilarWnt inhibitors that bind LRP5/6 include the Dickkopf (Dkk) and. WISE/SOST

Ligands Wnts Receptors frizzled LRP5/6 frizzled LRP5/6 Kinases Axin APC Dsh

https://www.diva-portal.org/smash/get/diva2. /FULLTEXT01.pdfCachedSimilarinduced secreted protein (WISE), Wnt inhibitory factor-1 and. -2 (Wif-1, Wif-2) and

https://www.frontiersin.org/articles/252437CachedSimilarThe more distant members (middle) are the NPxY-lacking Lrp5/Lrp6 and hybrid

www.mdpi.com/2221-3759/5/4/10/pdfCachedOct 15, 2017 . proteins such as WISE, SOST or DKK [4]. . .. highly conserved PPT(S/T)Px(S/T)

cshperspectives.cshlp.org/content/5/3/a015081.fullSimilarOct 19, 2012 . Wise also binds the LRP4 receptor (Ohazama et al. 2008), which is able to

citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.624. CachedSep 1, 2008 . 5 and 6 (LRP5/6), are required for transducing the Wnt signal. LRP5/6 is . Wise

grantome.com/grant/NIH/R01-AR053949-02S1CachedThe Principal Investigator identified a gene, Lrp5, responsible for high bone .

www.sdbonline.org/fly/segment/arrow2.htmCachedSimilarThe gene, termed low-density lipoprotein receptor related protein 5 (LRP5), . .

https://mutagenetix.utsouthwestern.edu/. /phenotypic_rec.cfm?pk=271CachedIGL00834:Lrp5, APN, 19, 3649404, unclassified, probably benign . . of β-

https://bmcmedgenet.biomedcentral.com/articles/. /1471-2350-13-26CachedSimilarMutations in LRP5 cause primary osteoporosis without features of OI by reducing

https://www.semanticscholar.org/. /Wise. / 02b1b483e7ece65cd1eddc7afb97c99e1daffcb0This change in proliferation is dependent upon Lrp5, as Wise;Lrp5 double

https://academic.oup.com/jcem/article-pdf/90/12/6741/. /jcem6741.pdfties up LRP5 by binding to it and another membrane protein called Kremen.

www.hormones.gr/preview.php?c_id=194CachedSimilarSost and its homolog Wise belong to the cysteine knot protein subfamily and

digitalcommons.wustl.edu/open_access_pubs/2940/Ellies DL, Economou A, Viviano B, Rey J-P, Paine-Saunders S, et al. (2014) Wise

journals.sagepub.com/doi/10.1177/154405910808700509SimilarG.E. Wise* . . Cielinski MJ, Jolie M, Wise G, Ando D, Marks SJ -1994-. . . The

Indeed, it appears that in the absence of Krm, Dkk2 binding to LRP5/6 activates .

https://www.sciencedirect.com/science/article/pii/S0969212611002474Oct 12, 2011 . First structure of any domain from Wnt coreceptors LRP5/6 (LRP6 E1 . 2001)

dev.biologists.org/content/131/8/1663SimilarWe discuss Arrow/Lrp5/Lrp6 interactions with Wnt and the Frizzled family of Wnt

www.pnas.org/content/pnas/early/2015/02/26/1419714112.full.pdfFeb 26, 2015 . receptor complex of frizzled and Lrp5/6 leads to accumulation of cytoplasmic . ..

https://www.researchgate.net/. /262025317_Wise_Regulates_Bone_ Deposition_through_Genetic_Interactions_with_Lrp5?_. Dec 19, 2017 . Full-Text Paper (PDF): Wise Regulates Bone Deposition through Genetic

www.columbia.edu/cu/biology/dept/seminarPDFfiles/mol.cell.pdfCachedSimilarJan 16, 2004 . brate LRP5 or LRP6 and the Drosophila arrow gene. LDL receptor related

https://blogs.shu.edu/. /oncomeds-wnt-targeted-experimental-cancer-drugs- and-bone-related-adverse-events/CachedJun 15, 2014 . Axin moves to the LRP5/6 tail at the membrane through its interaction .

www.journal-of-hepatology.eu/article/S0168-8278(13)00445-5/pdfSimilarWise and Sost pro- teins form the other class of secreted antagonists. They bind

However, Lrp5/6/Arrow function as signaling molecules and participate with

diposit.ub.edu/dspace/. /1/BEHJAT%20GHOLAMI_PhD_THESIS.pdfIn vivo interaction of RUNX2 to 5 elements on the human LRP5 upstream . ..

dev.biologists.org/content/develop/137/19/3221.full.pdf?with-ds=yesReducing the dosage of the Wnt co-receptor genes Lrp5 and Lrp6 rescues the

https://resources.rndsystems.com/pdfs/datasheets/7344-lr.pdfThe lowdensity lipoprotein (LDL) receptorrelated proteins LRP5 and LRP6 (LRP5

https://www.ncbi.nlm.nih.gov/pubmed/24789067May 1, 2014 . Wise regulates bone deposition through genetic interactions with Lrp5. Ellies DL(

www.oarsijournal.com/article/S1063-4584(05)00027-0/fulltextHaplotypes of the low-density lipoprotein receptor-related protein 5 (LRP5) gene:

www.biomedsearch.com/attachments/00/19/. /jbmr0024-0171.pdfCachedSimilarDec 15, 2008 . nective tissue growth factor and Wise) bind and regulate the activity of Lrp5 and

www.elm.eu.org/elms/LIG_LRP6_Inhibitor_1.htmlCachedThe binding of Wnt antagonists to the first β-propeller domain of LRP5/6 .

stke.sciencemag.org/cgi/content/full/5/224/pe22SimilarMay 15, 2012 . The full-length LRP5/6 can be divided into the ectodomain (ECD), . WISE and

www.informatics.jax.org/allele/MGI:5617945CachedGenetic correction of Wise with Lrp5 during ossification. Show the 1 phenotype

onlinelibrary.wiley.com/doi/10.1359/jbmr.060810/pdfSimilarAug 21, 2006 . Wise and Sost (Sclerostin). Our data suggest that functional interactions between

https://www.nature.com/articles/ncomms7906.pdf?origin=ppubApr 22, 2015 . wise-nonaggressive tumour cells to migrate in vitro, whereas a soluble . LRP5/6

https://www.omim.org/entry/604270CachedSimilar(2011) found that sclerostin (SOST; 605740) interacted with LRP4, LRP5 (

EGF repeat Cytoplasm Wnt LRP5/6 Frizzled Kremen ß-catenin FIGURE 3 .

https://www.ncbi.nlm.nih.gov/pubmed/17002572SimilarOur data suggest that functional interactions between Sost or Wise and LRP5/

dx.doi.org/10.1359%2Fjbmr.060810Our data suggest that functional interactions between Sost or Wise and LRP5/

https://www.futuremedicine.com/doi/10.2217/14796694.1.5.673Sep 22, 2005 . Southern Research Institute, Biochemistry and Molecular Biology Department,

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