digital.csic.es/bitstream/10261/. /1/Ayala_FemsMicroRev_234.pdfCachedSimilarPereira, et al., 2007) but resistant strains have acquired an additional PBP,

https://www.escmid.org/escmid_publications/escmid_elibrary/material/?. ALLOSTERIC SITE MISSENSE MUTATIONS IN PBP2A AFFECTING . These

www.jbc.org/content/279/39/40802.fullSimilarSep 24, 2004 . Penicillin-binding protein 2a (PBP2a) of Staphylococcus aureus is . .. 1A, the x-

www.uniprot.org/uniprot/O70039CachedSimilarpbp2a. Organism. Streptococcus pneumoniae. Status . Name:pbp2aImported. <

https://www.bnl.gov/isd/documents/26322/sh_life_sci_3.pdfCachedSimilarThe three-dimensional structure of PBP2a, determined by researchers at the

www.rcsb.org/pdb/explore.do?structureId=3ZG5CachedSimilarThe high-molecular mass penicillin binding proteins of bacteria catalyze in separate domains the transglycosylase and transpeptidase activities required for the biosynthesis of the peptidoglycan polymer that comprises the bacterial cell wall.

discovery.ucl.ac.uk/. /1/Sarah%20Paulin_26.6.14%20final-corrected.pdfImpact of epicatechin gallate on the structural integrity of the PBP2/PBP2a

https://www.ncbi.nlm.nih.gov/pubmed/12389036Additionally, structures of the acyl-PBP complexes of PBP2a with nitrocefin, penicillin G and methicillin allow, for the first time, a comparison of an apo and acylated resistant PBP.

https://academic.oup.com/jac/article-pdf/71/1/34/6994686/dkv329.pdfOct 19, 2015 . PBP2a mutations located in the ceftaroline-binding pocket, Y446N or . . tified in

www.ajpcr.com/Vol5Suppl1/767.pdfCachedSimilarThe crystal structure of a soluble derivative of PBP2a has been determined to 1.8

https://vnu.edu.vn/. /C-09-7-12-NguyenHoaMi-TA-8_7_2012.pdfCachedOfficial thesis number: Study on mechanism for reaction of PBP2a with β-lactams

https://jac.oxfordjournals.org/content/71/1/34.fullOct 19, 2015 . The structures of S. aureus PBP2a, in the apo form (PDB:1VQQ) and in complex

www.nature.com/nsmb/journal/v9/n11/full/nsb858.htmlSimilarOct 21, 2002 . The crystal structure of PBP2a presented here reveals structural features

bipublication.com/files/jabr-V5I1-2014-4.pdfCachedSimilaralignment was shown with 1VQQ PDB sequence and 1VQQ sequence was

vm-trypanocyc.toulouse.inra.fr/gene?orgid=META&id. 15469CachedSince penicillins contain a structure element that is similar to the D-Ala-D-Ala

PBP2a from S. pneumoniae exhibits a much lower affinity for b-lactam .

onlinelibrary.wiley.com/doi/10.1111/j.1574-6976.2008.00105.x/fullSimilarFeb 11, 2008 . The penicillin-binding proteins: structure and role in peptidoglycan . . More

www.proteinscope.com/CA-MRSA.pptCachedSimilarArticle Title. Structural basis for the beta lactam resistance of PBP2a from

journals.plos.org/plosone/article?id=10.1371/journal.pone. CachedSimilarMay 9, 2011 . The crystal structure of PBP2a in both its apo form and complexed to β-lactams

https://www.researchgate.net/. /271529781_fig3_Figure-3-Crystal-structure- of-S-aureus-PBP2a-in-complex-with-quinazolinone-2-AFigure 3. Crystal structure of S. aureus PBP2a in complex with quinazolinone 2 . (

www.pnas.org/content/110/42/16808.full.pdfSimilarOct 15, 2013 . in the gene for PBP2a that confer resistance to ceftaroline, and provide the

https://www.escholar.manchester.ac.uk/api/datastream?. uk. CachedSimilar1.2.3 Barrett: Synthesis of ABCD ring structure utilising an intramolecular . ..

www.sciencedirect.com/science/article/pii/S1198743X14609563Hence, PBP2a is responsible for the intrinsic resistance of MRSA to almost all .

https://en.wikipedia.org/wiki/MecA_(gene)CachedSimilarThe mecA gene is a gene found in bacterial cells. The mecA gene allows a

pubmedcentralcanada.ca/pmcc/articles/PMC4686279/The recently published crystal structure of the complex of PBP2a with ceftaroline,

pubs.rsc.org/-/content/articlepdf/2014/mb/c4mb00319eSep 25, 2014 . performed with 37 quercetin derivatives towards PBP2a inhibition and their

https://s3-eu-west-1.amazonaws.com/pstorage-acs. /ja5030657_si_001.pdfStructures were solved by molecular replacement using the PHASER program7

pubs.acs.org/doi/pdf/10.1021/jacs.6b12565complished computationally in reference to the known “closed” apo-PBP2a X-ray

mic.microbiologyresearch.org/content/. /10. /mic.0.29078-0?. CachedSimilarhave indicated that the resistance protein PBP2A may also function in contexts

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4236225/Jul 14, 2014 . Lim and Strynadka published the first crystal structure of soluble PBP2a at 1.8 Å

https://www.slideshare.net/MuhammadTalaat1/pbp2aCachedDec 28, 2016 . PBP2A Penicillin Binding Protein 2a Introduced to; Dr. Eman . Peptidoglycan

www.mdpi.com/2079-6382/5/1/12/pdfCachedFeb 17, 2016 . The X-ray structure of PBP2a in complex with ceftobiprole [66] and with

FUNCTION OF PBP2A IN PEPTIDOGLYCAN METABOLISM One of the genetic

MRSA with slow PBP2a induction often display low oxacillin MICs. . PBP2a Lim

www.mdpi.com/1420-3049/17/11/12478/pdfCachedSimilarOct 24, 2012 . structure based design, have allowed the development of new molecules. . .

jb.asm.org/content/187/5/1815.fullSimilarDisruption of pbpD, the structural gene of PBP4, in either the parental strain or .

www.hhmi.org/. /structure-based-antibiotic-discovery-bacterial-membraneCachedSimilarWe have determined, to high resolution, the crystal structures of native MRSA

www.biomedsearch.com/attachments/00/22/97/72/. /zbc36854.pdfCachedSignificance: This study provides insights into the relationship between structure

www.nature.com/scibx/journal/v6/n41/full/scibx.2013.1172.htmlSimilarOct 24, 2013 . In vitro studies identified an allosteric site on PBP2a that could aid the

The view of the cortex as a loosely crosslinked, negatively charged structure has

The transglycosylase domain of PBP2a was shown to catalyze the . genes in

www.xtal.iqfr.csic.es/grupo/xjuan/. /cell-wall-remodeling.htmlCachedSimilarThe structural and functional aspects of catalysis by NagZ were investigated by a

Biochemical studies have been limited, although the crystal structure of the .

https://crystallography365.wordpress.com/page/11/CachedOct 24, 2014 . Where did the structure come from? This is the structure of a mecA gene encoded

www.tandfonline.com/doi/full/10.1080/07391102.2015.1092096?src. May 4, 2016 . The 3D structure of the PBP2a (PDB ID: 3ZG0, 2.60 Å), co-crystallized with two

proteopedia.org/wiki/index.php/Sandbox_126CachedJul 31, 2014 . . a highly polymeric "mesh" that helps maintain the structural strength of .

https://pdfs.semanticscholar.org/. / 73fb034e8c1cb7181770ec3f6b8b1a745c89.pdfCachedApr 28, 2014 . these mutations was analysed using the known X-ray structure of S. aureus

www.ajmb.org/article/126Cloning, Expression and Purification of Penicillin Binding Protein2a (PBP2a) . S.

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