Patent #: 5321014. Issued on: 06/14/1994. Inventor: Janz, et al. Cyclodextrin/drug

T Loftsson, et al., “The effect of water-soluble polymers on drug-cyclodextrin

klassischen Verfahren hergestellt worden (Kurozumi et al., 1975; Nozawa et al.,

. provided a 9.4-fold enhancement (Vollmer et al., 1994). . on the donor

(1994). 69. T. Loftsson et al.,“Topically Effective Ocular. Hypotensive

J. Jablan et al., Inclusion Complexes of Zaleplon with Cyclodextrins. Croat. Chem

We have observed that addition of a very small amount of polymer can increase

than given material (Cassell et al. 1994). Loftsson, Vilhjálmsson .

Cyclodextrins in topical formulations for ocular drug delivery. Drug. Cyclodextrin.

Nov 9, 2006 . ther methylation (Frömming and Szejtli, 1994). Later several . . (Riley et al., 1991;

May 15, 2006. compounds (Harada, 2001; Redenti et al., 2001; Loftsson et al., 2004). .

Loftsson T, Gudmundsdottir H, Sigurjonsdottir JF, et al. Cyclodextrin

Jan 30, 2008 . hydrogen bonding (Loftsson et al., 1996; Stella et al.,. 1997). . poorly water

Solubility experiments (Loftsson et al., 1994b) have shown that the optimal

Nov 5, 1996 . 07/07/1994 . CA116:15328 Shah et al, "Human Albumin binding of tamoxifen in

Loftsson et al., 1994a T. Loftsson, H. Friðriksdóttir, S. Thórisdóttir and E.

Other investigators have shown that at low concentrations, polymers increase the

. SBE-β-CD and an anionic polymer (i.e., hexadimethrine bromide) (Loftsson et

. 7 -3.88 Tam et al., 1994 15 -3.73 Tam et al., 1994 25 -3.66 Tam et al., 1994 35

monitoring the flux of a drug through semi-permeable membranes (Loftsson et al.

EP0579435 - Cyclodextrin complexation [ Right-click to .

Dec 5, 2003 . (Kondo et al, 1996; Uekama et al, 1995) CDs have also been used to . .. Loftsson

Aug 22, 2010 . For example,Loftsson et al., Drug Development and Industrial Pharmacy, .

Hrafn Loftsson, Jökull H. Yngvason, Sigrún Helgadóttir and Eiríkur . In 2000, the

(2009) Mauludin et al. European journal of . al., 2004; Loftsson and Brewster,

could be obtained (Loftsson et a1 1994). The purpose of this present

Further, excess of the complexing host molecules in a formulation can reduce the

1996; Ratnaparkhi 1996; Brants 2000; Toutanova et al. . et al. 1996), TnT (

into the eye (Loftsson et al 2006a; Loftsson & Stefánsson 2007). Passive drug . ..

Loftsson T, Bodor N. The pharmacokinetics and transdermal delivery of

. Oliveira, 1999; Dalmora et al., 2001; Loftsson et al., 2001; Másson et al., 1998).

Water-soluble polymers can form co-complexes with cyclodextrins and drugs (

(Loftsson et al., 1994, Loftsson et al., 1996, Granero et al., 2010) . (Usayapant et

Bellanger and Perly, 1994; Bonini et al., 2006; Coleman and. Nicolis, 1992;

conducted by Flach et al., topical application of acetazolamide . . Loftsson et al.

than given material (Cassell et al. 1994). Loftsson, Vilhjálmsson .

1994; Loftsson et aL, 1989; Chang and Banga, 1996). However, the

ELSEVIER International Journal of Pharmaceutics 104 (1994) 181-184 . CD

T Loftsson, et al., “Methods to enhance the complexation efficiency of

Oct 20, 2011 . This was noted by Mwakibete et al.,(19) who proposed a two-class categorization

article, have been discussed in numerous reviews and books. (Duchéne, 1987;

. ([Corrigan and Stanley, 1982, Loftsson et al., 1990, Loftsson et al., 1994,

(Bibby et al., 2001; Hirayama, Uekama, 1999; Szejtli,. 1994; Loftsson, Másson,

mmol; C*Cavitron 82005, Cerestar USA, Inc., Hammond, IN,. USA; ds = 4.5) and (

Feb 24, 2011 .

2001; Loftsson et al. 2003b). Cyclodextrins are able to alleviate local drug

. enhances the efficiency of drug-cyclodextrine complexation. This solubilization

Lappalainen, et al., 1994) and consequently leading to cell death via the .

T. Loftsson, H. Fridriksdbttir, G. Ingvarsddttir, B. Jbnsdbttir and A.M. . Copyright 0

(Scheme 3) (Bodor, 1977; Druzgala et al., 1992). . Woltersdorf et al., 1989) and

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