The frequency and selective impact of deleterious mutations are fundamental

RNA deleterious mutations have attracted wide attentions because some of them

suggests a downwardly biased genomic deleterious mutation rate of 0.1 and a .

Key words: chloroplast genome, deleterious mutation, mitochondrial genome,

Aug 6, 2008 . Deleterious mutation. These are the words printed on a navy blue pocketed

The rate and average effects of spontaneous deleterious mutations are . can

numbers of deleterious mutations introduced and remaining in the genome of an

Oct 29, 2010 . Deleterious mutation poses a serious threat to human health and the persistence

In theoretical population genetics, it is more usual to speak of such mutations as

Top questions and answers about Deleterious Mutation. Find 15 questions and

Mar 3, 2011 . Excess of de novo deleterious mutations in genes associated with glutamatergic

Deleterious mutations reduce fitness within natural populations and must be

Unconditionally deleterious mutations could be an important source of variation

Though it is not practical to eliminate all deleterious mutation, the incidence of

Oct 2, 1998 . It is well established on theoretical grounds that the accumulation of mildly

Mildly deleterious mutation has been invoked as a leading explanation for a

A woman's risk of developing breast and/or ovarian cancer is greatly increased if

Sep 16, 2009 . Including coding and noncoding sites, we estimate that the genomic deleterious

Mar 1, 2011 . Deleterious Mutations of a Claw Keratin in Multiple Taxa of Reptiles. Authors:

Jul 1, 2008 . I received a piece of paper that said I was positive for a “deleterious mutation,”

Here we review the impact of this effect by considering the gradual selective

One, the deleterious mutation hypothesis, was the idea that sex exists to purge a

bias some estimates of the genomic rate of deleterious mutation. These effects

Multisite 3 BRACAnalysis® POSITIVE FOR A DELETERIOUS MUTATION.

This test is focused on looking for the same gene mutation on the BRCA1 or

The accumulation of deleterious mutations can drastically reduce population

assumed to be equally deleterious and rare, so that homozygous mutations can

Jul 31, 2011 . Abstract Deleterious mutation accumulation plays a central role in evolutionary

Methods for automated prediction of deleterious protein mutations have utilized

Oct 12, 2009 . Women with a deleterious gene mutation are diagnosed with breast cancer six

Mar 11, 2008 . Since real populations are finite and also subject to recurrent deleterious

identification of both unambiguously defined deleterious mutations and

Sep 22, 2011 . One postulated benefit of sex and recombination is that they facilitate the purging

Kondrashov, among others, has tried to show that sex reduces the effects of

Aug 2, 2011 . Last Friday I learned that I'm a carrier for the BRCA2 gene mutation. Actually, the

When is a single base substitution mutation least likely to be deleterious? when

Aug 25, 2011 . Sung Chun, Justin C. Fay. PLoS genetics, Vol. 7, No. 8. (25 August 2011),

It has been suggested that humans may suffer a high genomic deleterious

Jun 1, 1995 . Deleterious mutation and the evolution of genetic life cycles. - Find Evolution

(1988) Kondrashov. Nature. Read by researchers in: 100% Biological Sciences.

We study the dynamics of adaptation in asexual populations that undergo both

. of an asexual population accumulate deleterious mutations in an irreversible .

Jun 30, 2011 . This research is part of my PhD thesis which I started in 2007, in part inspired by

Characterization of BRCA1 and BRCA2 deleterious mutations and variants of

Jan 19, 2011 . Purifying selection against deleterious mutations increases the . Moreover,

Oct 13, 2000 . If rates of deleterious mutation per diploid genome per generation (U) exceed 1,

May 23, 1999 . Almost all mutations which aren't silent and which aren't eliminated immediately

Jan 13, 2011 . What it shows is that the mean fitness of a population drops as you increase the

Kim HJ. Novel deleterious mutation in the F12 gene in a Korean family with

The rate of accumulation of deleterious mutations has im- portant consequences

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