In ~60% of neuroblasts that overexpress Sak, centrosomes are amplified, and

Dec 27, 2007 . Cancer cells contain an abnormal number of chromosomes (aneuploidy), which

Sep 26, 2011 . Cuomo, M. E., Knebel, A., Morrice, N., Paterson, H., Cohen, P., Mittnacht, S. (2008

Dec 23, 2009 . Zinc chromate also induced centrosome amplification in a concentration- and

Jul 15, 2011 . NF-κB induces abnormal centrosome amplification by upregulation of CDK2 in

However, whether centrosome amplification could directly cause aneuploidy is

Mar 14, 2011 . Here, we used light and electron microscopy to show that DNA damage induces

These findings indicate that abnormal centrosome amplification can occur in

Dec 18, 2010 . centrosomes leads to centrosome amplification (presence of more than .

with the centrosome during interphase, but not during mitosis (6). To investigate.

Pin1 Regulates Centrosome Duplication, and Its Overexpression Induces

Jul 25, 2011 . Centrosome amplification, the presence of extra centrosomes, is found in many

Abstract. The turn of the 21st century had witnessed a surge of interest in the

Centrosomal amplification, identified by a pericentrin antibody and evidenced .

Nov 15, 2010 . Abstract. Extra centrosomes are found in many tumors, and their appearance is

(2004) Salisbury et al. Journal of Mammary Gland Biology and Neoplasia. Read

Apr 12, 2010 . Spontaneous and 5-fluorouracil-induced centrosome amplification lowers the

Jan 8, 2010 . Centrosome amplification was significantly higher in recurrent and malignant

Feb 19, 2002 . Earlier studies of invasive breast tumors have shown that 60–80% are aneuploid

Centrosome amplification has been implicated as the cause of chromosomal

Chromosome instability is a hallmark of cancer, because it promotes the

Jan 27, 2011 . Because centrosome amplification generates aneuploidy and since centrosome

mechanisms leading to centrosome amplification in breast cancer; second, they

somes (centrosome amplification), which could lead to aberrant mitoses and .

that centrosome amplification is normally inhibited by deg- radation of SAK/PK4

Jun 13, 2008 . Centrosome Amplification Can Initiate Tumorigenesis in Flies. Renata Basto1, 6,

On The Origin Of Centrosome Amplification And Chromosomal Instability In.

Centrosome amplification is a common feature of many can- cer cells (D'Assoro

Centrosome amplification frequently occurs in human cancers and is a major

Dec 8, 2005 . Centrosome amplification, chromosome instability and cancer development.

Centrosome amplification and overexpression of aurora A are early events in rat

Jan 14, 2011 . Centrosome amplification, the presence of extra centrosomes, is found in . How

Tumour amplified kinase STK15/BTAK induces centrosome amplification,

Titre du document / Document title. Induction of centrosome amplification and

Increased centrosome number, or centrosome amplification, is a common

Jul 1, 2004 . Centrosome Amplification and the Origin of Chromosomal Instability in Breast

One potential cause of mitotic catastrophe is centrosome amplification, which is

Centrosome Amplification and a Defective G2–M Cell Cycle Checkpoint Induce

Dec 11, 2008 . The SCF/Slimb Ubiquitin Ligase Limits Centrosome Amplification through

Aug 9, 2006 . During interphase, each cell contains a single centrosome that acts as a

Feb 1, 2011 . The "moment" of centrosome amplification in PCS(BubR1-mutated) syndrome

Sep 9, 2004 . Centrosome amplification induced by DNA damage occurs during a prolonged

Finally, Plkl depletion ele significantly reduces centrosome amplification in

Tsuda M. A novel pathway of centrosome amplification that does not require DNA

Jan 7, 2005 . Here we document that transient cyclin D1 expression induced centrosome

Jan 28, 2011 . Human Embryonic Stem Cells Suffer from Centrosomal Amplification†‡§. Zuzana

Nov 21, 2002 . SpringerImages - Centrosome amplification in p53-/- Clara cells.

Aurora-A overexpression reveals tetraploidization as a major route to centrosome

Jun 19, 2008 . Following these dramatic early changes, the cell population rapidly converges

Seminars in Cancer Biology 15 (2005) 25–32. Review. Centrosomal

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