www.tandfonline.com/doi/pdf/10.4161/cc.26582Aug 23, 2013 . The tumor suppressor proteins 53BP1 and BRCA1 have emerged as key . cycle

f1000.com/prime/reports/b/1/21/SimilarMar 17, 2009 . Although the majority of NHEJ occurs independently of ATM signalling, recent

jcs.biologists.org/content/126/14/3095/F7.expansion.htmlJul 15, 2013 . (A) Wild-type Sertoli cells (arrows) show strong diffuse 53BP1 fluorescence (red)

mcb.asm.org/content/early/2014/01/22/MCB.01639-13.full.pdfSimilarJan 27, 2014 . 53BP1, first identified as a DNA damage checkpoint protein, . . removal of 53BP1

www.filetypepdf.com/53/53bp1-nhej-pdf.htmlCachedin terms of how far it can spread from the site of DNA damage (Box 2). 53BP1

delangelab.rockefeller.edu/pubs/24094932.pdfCachedThe choice between. HDR and c-NHEJ is regulated such that DSBs formed in S

www.jbc.org/content/278/38/36487.fullSimilarSep 19, 2003 . We show that 53BP1 changed its localization from the detergent soluble to . In

www.readcube.com/articles/10.1038%2Fnature07433To address the mechanism by which 53BP1 promotes NHEJ, we used time-lapse

https://globalmedicaldiscovery.com/. /53bp1-promotes-microhomology- mediated-end-joining-in-g1-phase-cells/CachedSimilarMar 5, 2015 . The functions of 53BP1 in NHEJ processes are not well understood. Here, we

https://www.sciencemag.org/content/339/6120/700.full.pdfFeb 8, 2013 . or nonhomologous end joining (NHEJ) is tightly regulated. Defects in this .

journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen. CachedSimilarAug 28, 2014 . Both NHEJ and HR, in particular NHEJ, promoted anaphase-bridge . or A-NHEJ

www.omim.org/entry/605230CachedSimilarTo address the mechanism by which 53BP1 promotes NHEJ, Dimitrova et al. (

162.105.205.69/data/. /2DongyiXu-MolecularCell_YBDBqY.pdfCachedSimilara consequence, NHEJ is inhibited by end resection, the process by which 50-30

www.divirgiliolab.com/research.htmlCachedSimilarThe key regulator of DNA end processing is the DNA repair factor 53BP1, whose

europepmc.org/abstract/MED/18931659SimilarDouble-strand breaks activate the ataxia telangiectasia mutated (ATM) kinase,

www.fasebj.org/content/28/1_Supplement/LB120.shortSimilarPrevious studies show non-homologous end-joining (NHEJ) protein and ATM

www.jmcb.info/arts.asp?id=534CachedSimilar53BP1 and other DNA damage response (DDR) proteins form foci at . localized

www.clinicalepigeneticsjournal.com/content/. /1868-7083-3-4-1.pdfCachedChromatin relaxation. DSB. Activation of PI3K-like kinases. (ATM, ATR, DNA-PK).

onlinelibrary.wiley.com/doi/10.1038/embor.2013.99/fullJul 12, 2013 . In response to DSBs, 53BP1 binds to chromatin at damaged sites, where it

digital.csic.es/bitstream/10261/60990/1/Lamins,%20guardians.pdfCachedby ionizing radiation, apparently in a 53BP1- dependent manner. The

www.ncbi.nlm.nih.gov/pubmed/25916843Apr 27, 2015 . Ectopic expression of RNF168 and 53BP1 increases mutagenic but not

www.pubfacts.com/. /53BP1-is-limiting-for-NHEJ-repair-in-ATM-deficient- model-systems-that-are-subjected-to-oncogenic-strMechanistically, 53BP1 deficiency aggravated the deleterious effect of ATM

. Chromatin remodeling IIa HDAC4 53BP1 NHEJ and HRR downregulation

lowdose.energy.gov/pdf/2006/oneill_p_06_abstractvi.pdfCachedSimilarCo-localisation of γ-H2AX and 53BP1 to sites of DNA double strand breaks .

https://grantome.com/grant/NIH/R01-CA181090-02CachedThis proposal is focused on the regulation of DSB repair by 53BP1, a DNA

www.sciencedirect.com/science/article/pii/S0092867410002850Similar53BP1 and Brca1 regulate the choice between HR and NHEJ pathways for DNA

www.genomeintegrity.com/content/pdf/2041-9414-3-9.pdfCachedSimilarNov 27, 2012 . while NHEJ is active throughout the cell cycle and does not rely on a template.

figshare.com/articles/_53BP1. in. NHEJ_is. _/1212139CachedOct 22, 2014 . The recombination substrates are diagrammed on the right with details described

www.researchgate.net/. 53BP1. /0046353750b129927f000000.pdfCachedSimilarFeb 3, 2010 . the DNA damage response factors, 53BP1 has the most profound effect on CSR

nar.oxfordjournals.org/content/early/2013/08/22/nar.gkt729.fullSimilarAug 22, 2013 . Next, we examine roles for 53BP1 and BRCA1 in this process. Previous studies

https://www.addgene.org/browse/article/2344/Cached53BP1 promotes non-homologous end joining of telomeres by increasing

www-06.all-portland.net/bst/037/0897/0370897.pdfCachedSimilar53BP1 (p53-binding protein 1) is classified as a mediator/adaptor of the DNA-

www.ncbi.nlm.nih.gov/pubmed/18931659SimilarNature. 2008 Nov 27;456(7221):524-8. doi: 10.1038/nature07433. Epub 2008

www.pnas.org/content/110/6/2146.abstractSimilarFeb 5, 2013 . First, the requirements for 53BP1 in mediating NHEJ at dysfunctional telomeres

www.nature.com/nrm/journal/v15/n1/box/nrm3719_BX1.htmlSimilarDec 11, 2013 . The two main DNA double-strand break (DSB) repair pathways in eukaryotic

www.ncbi.nlm.nih.gov/pubmed/23858098SimilarMol Cancer Res. 2013 Oct;11(10):1223-34. doi: 10.1158/1541-7786.MCR-13-

jem.rupress.org/content/207/4/855SimilarApr 5, 2010 . We propose that 53BP1 favors long-range CSR in part by protecting DNA ends

https://tspace.library.utoronto.ca/. /Harding_Shane_M_201211_PHD_Thesis. pdfCachedSimilarThe tumour suppressor p53-binding protein 1 (53BP1) is phosphorylated

www.crick.ac.uk/research/a-z-researchers/researchers-a. /projects/CachedIn recent work, we established that Rif1-/- mice are severely compromised for

adsabs.harvard.edu/abs/2008Natur.456..524DTitle: 53BP1 promotes non-homologous end joining of telomeres by increasing

www.slas.ac.cn/upload/20130815-2.pdfCachedSimilarJun 12, 2013 . we elucidate how vertebrate 53BP1 is recruited to the chromatin that . (NHEJ)3

gradworks.umi.com/36/72/3672174.htmlCachedNext we studied the unique function of 53BP1, a known NHEJ factor for DSB

www.ndm.ox.ac.uk/principal-investigators/researcher/ross-chapmanCachedSimilarWe have also recently identified RIF1 as the major effector protein during 53BP1-

genesdev.cshlp.org/content/24/16/1680.fullSimilarNHEJ is an alternative pathway in which two broken DSBs are sealed . .. the role

www.ncbi.nlm.nih.gov/pmc/articles/PMC3594748/SimilarThus, RIF1 and 53BP1 cooperate to block DSB resection to promote NHEJ in G1,

We previously found that loss of A-type lamins leads to degradation of 53BP1

https://www.wikigenes.org/e/ref/e/16644291.htmlCached53BP1 (p53 binding protein) is a BRCT domain-containing protein that is rapidly

https://www.dkit.ie/. /genetic-dissection-vertebrate-53bp1-major-role-non- homologous-end-joining-dna-double-strand-breaksCachedAug 19, 2014 . Title, Genetic dissection of vertebrate 53BP1: a major role in non-homologous

omicsonline.org/1948-5956/1948-5956-S1.028-004.pdfA novel role of 53BP1 in alternative non-homologous end joining. Junran Zhang.

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